Article

FRG1 Regulates Nonsense-Mediated mRNA Decay by Modulating UPF1 Levels

2025-11-18

Abstract excerpt

FRG1 acts as a molecular double-edged sword: while its overexpression is linked to facioscapulohumeral muscular dystrophy (FSHD), it’s under expression activates tumorigenic signalling pathways—highlighting the importance of tightly regulated FRG1 levels. Although prior studies have hinted at FRG1’s involvement in RNA biogenesis, its core molecular functions have remained largely elusive. Our previous work identif...

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Literature Corpus work: 403dfd99-0167-5043-8f7d-f454fb910c0a
DOI: 10.1101/2025.11.18.689056

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