Article

Role of NuMA1 in breast cancer stem cells with implications for combination therapy of PIM1 and autophagy inhibition in triple negative breast cancer

2024-04-01

Abstract excerpt

<title>Abstract</title> <p>Background: Nuclear mitotic apparatus protein 1 (NuMA1) is a cell cycle protein and upregulated in breast cancer. However, the role of NuMA1 in TNBC and its regulation in heterogenous populations remains elusive. <h4>Methods:</h4> We performed CRISPR mediated deletion of NuMA1 in mouse TNBC cells, BF3M. FACS was utilized to isolate BCSCs, and bulk cells based on CD29 and CD61 markers. C...

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Literature Corpus work: e5ccaedc-ac04-5f8d-83c7-6482e51cf565
DOI: 10.21203/rs.3.rs-3953289/v1

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