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Article

Tumor suppressor properties of the splicing regulatory factor RBM10.

RNA biology - 1 Jan 2016

Hernández Jordi, Bechara Elias, Schlesinger Doerte, Delgado Javier, Serrano Luis, Valcárcel Juan

Abstract excerpt

RBM10 is an RNA binding protein and alternative splicing regulator frequently mutated in lung adenocarcinomas. Recent results indicate that RBM10 inhibits proliferation of lung cancer cells by promoting skipping of exon 9 of the gene NUMB, a frequent alternative splicing change in lung cancer generating a negative regulator of Notch signaling. Complementing these observations, we show that knock down of RBM10 in...

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Source

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Identifiers

PMID: 26853560
DOI: 10.1080/15476286.2016.1144004
PMCID: PMC4841610

Genes

RBM10
NUMB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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