Article
Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks.
Genome research - 1 Jun 2016
Sebestyén Endre, Singh Babita, Miñana Belén, Pagès Amadís, Mateo Francesca, Pujana Miguel Angel, Valcárcel Juan, Eyras Eduardo
Abstract excerpt
Alternative splicing is regulated by multiple RNA-binding proteins and influences the expression of most eukaryotic genes. However, the role of this process in human disease, and particularly in cancer, is only starting to be unveiled. We systematically analyzed mutation, copy number, and gene expression patterns of 1348 RNA-binding protein (RBP) genes in 11 solid tumor types, together with alternative splicing...
Topics
- Alternative Splicing
- Amino Acid Motifs
- Binding Sites
- Cell Proliferation
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genome, Human
- Humans
- Mutation
- Neoplasms