Alternative splicing of NUMB correlates with tumor immune evasion and metabolic adaptation

Abstract excerpt

Alternative splicing of the NUMB gene at exon 9 generates protein isoforms linked to tumor growth and metastasis, but its impact on the tumor immune microenvironment remains unclear. Using RNA sequencing data from over 5,000 tumors across 16 cancer types, including breast cancer subtypes, we found that tumors with high NUMB exon 9 inclusion exhibit lower expression of immune-related genes, reduced immune cell in...

Topics

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• Alternative Splicing
• Amino Acid Motifs
• Cell Proliferation
• Gene Expression Regulation, Neoplastic
• Genome, Human
• Neoplasms
• RNA Splicing Factors
• Transcriptome

Identifiers and source

Literature Corpus work

c729a62c-d02b-5af7-a54f-7ff8e71b6f3e

DOI

10.1101/2025.08.11.669729