Article

The Human Leukocyte Antigen Locus and Susceptibility to Rheumatic Heart Disease in South Asians and Europeans

2019-07-26

Abstract excerpt

<h4>Background</h4> Rheumatic heart disease (RHD) remains an important cause of morbidity and mortality globally. Several reports have linked the disease to the human leukocyte antigen (HLA) locus but with negligible consistency. <h4>Methods</h4> We undertook a genome-wide association study (GWAS) of susceptibility to RHD in 1163 South Asians (672 cases; 491 controls) recruited in India and Fiji. We analysed direc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f416a019-1fcc-53b5-af14-a1cfb6a4d929
DOI: 10.1101/19003160

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Human Leukocyte Antigen Locus and Susceptibility to Rheumatic Heart Disease in South Asians and EuropeansDOI 10.1101/19003160Read

The Human Leukocyte Antigen Locus and Rheumatic Heart Disease Susceptibility in South Asians and Europeans.Semantic proximity Read

Association of HLA-DRB1*14 with rheumatic heart disease patients from Chandigarh, North India.Semantic proximity Read

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.Semantic proximity Read

Genome-wide analysis of genetic risk factors for rheumatic heart disease in Aboriginal Australians provides support for pathogenic molecular mimicrySemantic proximity Read

A genome-wide association study for rheumatoid arthritis replicates previous HLA and non-HLA associations in a cohort from South Africa.Semantic proximity Read

"HLA-G 3'UTR gene polymorphisms and rheumatic heart disease: a familial study among South Indian population".Semantic proximity Read

Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study.Semantic proximity Read

High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.Semantic proximity Read

Fine-mapping the human leukocyte antigen locus in rheumatoid arthritis and other rheumatic diseases: identifying causal amino acid variants?Semantic proximity Read

Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population.Semantic proximity Read

Genome-Wide Analysis of Genetic Risk Factors for Rheumatic Heart Disease in Aboriginal Australians Provides Support for Pathogenic Molecular Mimicry.Semantic proximity Read

Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levelsSemantic proximity Read