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Article

Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population.

PloS one - 1 Jan 2014

Næss Sigrid, Lie Benedicte A, Melum Espen, Olsson Marita, Hov Johannes R, Croucher Peter J P, Hampe Jochen, Thorsby Erik, Bergquist Annika, Traherne James A, Schrumpf Erik, Boberg Kirsten Muri, Schreiber Stefan, Franke Andre, Karlsen Tom H

Abstract excerpt

BACKGROUND: Genetic variants within the major histocompatibility complex (MHC) represent the strongest genetic susceptibility factors for primary sclerosing cholangitis (PSC). Identifying the causal variants within this genetic complex represents a major challenge due to strong linkage disequilibrium and an overall high physical density of candidate variants. We aimed to refine the MHC association in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25521205
DOI: 10.1371/journal.pone.0114486
PMCID: PMC4270690

Genes

NOTCH4
MICA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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