A genome-wide association study for rheumatoid arthritis replicates previous HLA and non-HLA associations in a cohort from South Africa.

doi:10.1093/hmg/ddac178

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Article

A genome-wide association study for rheumatoid arthritis replicates previous HLA and non-HLA associations in a cohort from South Africa.

Human molecular genetics - 16 Dec 2022

Mathebula Evans M, Sengupta Dhriti, Govind Nimmisha, Laufer Vincent A, Bridges S Louis, Tikly Mohammed, Ramsay Michèle, Choudhury Ananyo

Abstract excerpt

The complex pathogenesis of rheumatoid arthritis (RA) is not fully understood, with few studies exploring the genomic contribution to RA in patients from Africa. We report a genome-wide association study (GWAS) of South-Eastern Bantu-Speaking South Africans (SEBSSAs) with seropositive RA (n = 531) and population controls (n = 2653). Association testing was performed using PLINK (logistic regression assuming an...

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PMID: 35925860
DOI: 10.1093/hmg/ddac178
PMCID: PMC9759327

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