Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study.

doi:10.1001/jamacardio.2021.1627

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Article

Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study.

JAMA cardiology - 1 Sept 2021

Machipisa Tafadzwa, Chong Michael, Muhamed Babu, Chishala Chishala, Shaboodien Gasnat, Pandie Shahiemah, de Vries Jantina, Laing Nakita, Joachim Alexia, Daniels Rezeen, Ntsekhe Mpiko, Hugo-Hamman Christopher T, Gitura Bernard, Ogendo Stephen, Lwabi Peter, Okello Emmy, Damasceno Albertino, Novela Celia, Mocumbi Ana O, Madeira Goeffrey, Musuku John, Mtaja Agnes, ElSayed Ahmed, Elhassan Huda H M, Bode-Thomas Fidelia, Okeahialam Basil N, Zühlke Liesl J, Mulder Nicola, Ramesar Raj, Lesosky Maia, Parks Tom, Cordell Heather J, Keavney Bernard, Engel Mark E, Paré Guillaume

Abstract excerpt

Importance: Rheumatic heart disease (RHD), a sequela of rheumatic fever characterized by permanent heart valve damage, is the leading cause of cardiac surgery in Africa. However, its pathophysiologic characteristics and genetics are poorly understood. Understanding genetic susceptibility may aid in prevention, control, and interventions to eliminate RHD. Objective: To identify common genetic loci associated with...

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PMID: 34106200
DOI: 10.1001/jamacardio.2021.1627
PMCID: PMC8190704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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