Article
Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.
American journal of human genetics - 4 Aug 2016
Okada Yukinori, Suzuki Akari, Ikari Katsunori, Terao Chikashi, Kochi Yuta, Ohmura Koichiro, Higasa Koichiro, Akiyama Masato, Ashikawa Kyota, Kanai Masahiro, Hirata Jun, Suita Naomasa, Teo Yik-Ying, Xu Huji, Bae Sang-Cheol, Takahashi Atsushi, Momozawa Yukihide, Matsuda Koichi, Momohara Shigeki, Taniguchi Atsuo, Yamada Ryo, Mimori Tsuneyo, Kubo Michiaki, Brown Matthew A, Raychaudhuri Soumya, Matsuda Fumihiko, Yamanaka Hisashi, Kamatani Yoichiro, Yamamoto Kazuhiko
Abstract excerpt
Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is challenging. Here, we conducted a large-scale MHC fine-mapping analysis of rheumatoid arthritis (RA) in a Japanese population (6,244 RA cases and 23,731 controls) population by using HLA imputation, followed by a multi-ethnic validation...
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