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Single-cell clonal lineage tracing identifies the transcriptional program controlling the cell fate decisions by neoantigen-specific CD8 <sup>+</sup> T cells

2025-08-18

Abstract excerpt

Neoantigen-specific T cells specifically recognize tumor cells and are critical for cancer immunotherapies. However, the transcriptional program controlling the cell fate decisions by neoantigen-specific T cells is incompletely understood. Here, using joint single-cell transcriptome and TCR profiling, we mapped the clonal expansion and differentiation of neoantigen-specific CD8 + T cells in the tumor and draining...

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Literature Corpus work
f3c93af1-a5c9-5586-888f-aa17f6c282d9
DOI
10.1101/2025.08.13.670223
Open publication

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Single-cell clonal lineage tracing identifies the transcriptional program controlling the cell fate decisions by neoantigen-specific CD8 <sup>+</sup> T cellsDOI 10.1101/2025.08.13.670223
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