Article

Characterization of Cancer-Reactive T Cells and Neoantigen-specific T Cell Receptors

2025-10-30

Abstract excerpt

Not all tumor-infiltrating T cells are cancer-reactive (CR). Several studies have reported gene expression signatures associated with CR-T cells. To integrate these findings, we developed a computational workflow, CAT (Cancer-Associated T cells), which harmonizes existing CR-T cell signatures and applies them to identify CR-T cells across an atlas of one million T cells. Our findings reveal that the abundance of C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37133a4e-f5a3-5fb0-aeaf-1797c3d18d77
DOI: 10.1101/2025.10.29.685473

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of Cancer-Reactive T Cells and Neoantigen-specific T Cell ReceptorsDOI 10.1101/2025.10.29.685473Read

Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancersSemantic proximity Read

Turep: Detecting cross-cancer tumor-reactive T cells in single-cell and spatial transcriptomics dataSemantic proximity Read

The landscape of antigen-specific T cells in human cancersSemantic proximity Read

NeoTCR: An Immunoinformatic Database of Experimentally-supported Functional Neoantigen-specific TCR SequencesSemantic proximity Read

Investigation of Antigen-Specific T-Cell Receptor Clusters in Human CancersSemantic proximity Read

Mapping the landscape of T cell-recognized neoantigens in cancer patients.Semantic proximity Read

Tumor reactivity assessment using clonal expression (TRACE) reveals tumor reactive CD8 <sup>+</sup> T cell heterogeneity across solid tumorsSemantic proximity Read

A machine learning model that identifies neoantigen-reactive CD8+ T cells in human gastrointestinal cancerSemantic proximity Read

Identification and characterization of neoantigen-reactive CD8+ T cells following checkpoint blockade therapy in a pan-cancer settingSemantic proximity Read

A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancerSemantic proximity Read

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes.Semantic proximity Read

High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor controlSemantic proximity Read