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Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers

24 Feb 2022

Abstract excerpt

The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen-specific TCR clonotypes (NeoTCRs) from 10 metastatic human tumors to their single-cell transcriptomes, we identified signatures of CD8 + and CD4 + neoantigen-reactive tumor-infiltrating lymphocytes (TILs). Neoantigen-specific TILs...

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PMID: 35113651
DOI: 10.1126/science.abl5447

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