Article

LAG-3 blockade reactivates the CD8 <sup>+</sup> T cell expansion program to re-expand contracted clones in the tumor

2024-07-09

Abstract excerpt

Effective cancer immunotherapy relies on the clonal proliferation and expansion of CD8 + T cells in the tumor 1,2 . However, our insights into clonal expansions are limited, owing to an inability to track the same clones in tumors over time. Here, we developed a multi-tumor mouse model system to track hundreds of expanding and contracting CD8 + T cell clones over multiple timepoints in tumors of the same indivi...

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Literature Corpus work: d53219c7-f11c-52c6-b373-729a77483dab
DOI: 10.1101/2024.07.05.601623

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