Article
The spontaneous neoantigen-specific CD4+ T-cell response to a growing tumor is functionally and phenotypically diverse.
Journal for immunotherapy of cancer - 4 Sept 2025
Griswold Ryan Q, Brightman Spencer E, Soria Zavala Karla, Ordaz-Arias Manuel Azaid, Djassemi Navid, Thota Rukman R, Naradikian Martin S, Dose Hannah, Alarcon Suzie, Vijayanand Pandurangan, Peters Bjoern, Miller Aaron M, Cohen Ezra E W, Schoenberger Stephen P
Abstract excerpt
BACKGROUND: CD4+ T cells play a critical role in the positive and negative regulation of cellular immunity through the many functional subsets they comprise. The progressive growth of immunogenic tumors which nonetheless generate mutation-specific T cells suggests that effective immune control may be avoided or suppressed at the level of the neoantigen-specific CD4+ T-cell response. Despite their importance,...
Topics
- CD4-Positive T-Lymphocytes
- Antigens, Neoplasm
- Animals
- Mice
- Humans
- Phenotype