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The spontaneous neoantigen-specific CD4 + T cell response to a growing tumor is functionally and phenotypically diverse

2025-03-29

Abstract excerpt

CD4 + T cells play critical roles in the positive and negative regulation of cellular immunity through the many functional subsets they comprise. The progressive growth of immunogenic tumors which nonetheless generate mutation-specific T cells suggests that effective immune control may be avoided or suppressed at the level of the neoantigen-specific CD4 + T cell response. We used a tetramer specific for a valida...

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Literature Corpus work: 403d86ba-d83a-52a2-9002-1eadad825abf
DOI: 10.1101/2025.03.25.645281

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