Article

Clonal replacement of tumor-specific T cells following PD-1 blockade

2019-05-24

Abstract excerpt

Immunotherapies that block inhibitory checkpoint receptors on T cells have transformed the clinical care of cancer patients. However, which tumor-specific T cells are mobilized following checkpoint blockade remains unclear. Here, we performed paired single-cell RNA- and T cell receptor (TCR)-sequencing on 79,046 cells from site-matched tumors from patients with basal cell carcinoma (BCC) or squamous cell carcinoma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27515144-2907-5a7d-8eab-b287d11a6e61
DOI: 10.1101/648899

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clonal replacement of tumor-specific T cells following PD-1 blockadeDOI 10.1101/648899Read

Single-cell meta-analysis of T cells reveals clonal dynamics of response to checkpoint immunotherapySemantic proximity Read

Regional and clonal T cell dynamics at single cell resolution in immune checkpoint blockadeSemantic proximity Read

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapySemantic proximity Read

Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8 <sup>+</sup> T cell clone size and cytotoxicitySemantic proximity Read

Differentiation and Expansion of Tumor-Infiltrating T Cell Clonotypes Occurs in the Spleen Following Immune Checkpoint BlockadeSemantic proximity Read

T-cell repertoire diversity: friend or foe for protective antitumor response?Semantic proximity Read

Unravelling the heterogeneity and dynamic relationships of tumor-infiltrating T cells by single-cell RNA sequencing analysisSemantic proximity Read

Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinomaSemantic proximity Read

Induced B-Cell Receptor Diversity Predicts PD-1 Blockade Immunotherapy ResponseSemantic proximity Read

High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy responseSemantic proximity Read

Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer.Semantic proximity Read

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy responseSemantic proximity Read