Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.

doi:10.1016/j.cell.2021.08.020

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Article

Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.

Cell - 16 Sept 2021

Burger Megan L, Cruz Amanda M, Crossland Grace E, Gaglia Giorgio, Ritch Cecily C, Blatt Sarah E, Bhutkar Arjun, Canner David, Kienka Tamina, Tavana Sara Z, Barandiaran Alexia L, Garmilla Andrea, Schenkel Jason M, Hillman Michelle, de Los Rios Kobara Izumi, Li Amy, Jaeger Alex M, Hwang William L, Westcott Peter M K, Manos Michael P, Holovatska Marta M, Hodi F Stephen, Regev Aviv, Santagata Sandro, Jacks Tyler

Abstract excerpt

CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we found that immunodominance is established in tumors, wherein CD8 T cell expansion is predominantly driven by the antigen that most stably binds MHC. T cells responding to subdominant antigens...

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Identifiers

PMID: 34534464
DOI: 10.1016/j.cell.2021.08.020
PMCID: PMC8522630

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