Article

Within-sibship GWAS improve estimates of direct genetic effects

2021-03-07

Abstract excerpt

Estimates from genome-wide association studies (GWAS) represent a combination of the effect of inherited genetic variation (direct effects), demography (population stratification, assortative mating) and genetic nurture from relatives (indirect genetic effects). GWAS using family-based designs can control for demography and indirect genetic effects, but large-scale family datasets have been lacking. We combined da...

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Literature Corpus work: f36cb49f-0901-5511-9987-6e07df50d5bd
DOI: 10.1101/2021.03.05.433935

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