Article

Estimating genetic nurture with summary statistics of multi-generational genome-wide association studies

2020-10-08

Abstract excerpt

Marginal effect estimates in genome-wide association studies (GWAS) are mixtures of direct and indirect genetic effects. Existing methods to dissect these effects require family-based, individual-level genetic and phenotypic data with large samples, which is difficult to obtain in practice. Here, we propose a novel statistical framework to estimate direct and indirect genetic effects using summary statistics from...

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Literature Corpus work: 9265ca56-9776-5518-8203-e2cc28b55fe4
DOI: 10.1101/2020.10.06.328724

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