Article

Interpreting population and family-based genome-wide association studies in the presence of confounding

2023-02-27

Abstract excerpt

A central aim of genome-wide association studies (GWASs) is to estimate direct genetic effects: the causal effects on an individual’s phenotype of the alleles that they carry. However, estimates of direct effects can be subject to genetic and environmental confounding, and can also absorb the ‘indirect’ genetic effects of relatives’ genotypes. Recently, an important development in controlling for these confounds h...

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Literature Corpus work: 0f914d08-4ecc-5086-8e02-9c7e314bfd76
DOI: 10.1101/2023.02.26.530052

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