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Article

Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data.

Nature communications - 14 Sept 2021

Warrington Nicole M, Hwang Liang-Dar, Nivard Michel G, Evans David M

Abstract excerpt

Estimation of direct and indirect (i.e. parental and/or sibling) genetic effects on phenotypes is becoming increasingly important. We compare several multivariate methods that utilize summary results statistics from genome-wide association studies to determine how well they estimate direct and indirect genetic effects. Using data from the UK Biobank, we contrast point estimates and standard errors at individual...

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Identifiers

PMID: 34521848
DOI: 10.1038/s41467-021-25723-z
PMCID: PMC8440517

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