Article

Within-Family Validation of Polygenic Risk Scores and Complex Trait Prediction

2020-03-05

Abstract excerpt

We test a variety of polygenic predictors using tens of thousands of genetic siblings for whom we have SNP genotypes, health status, and phenotype information in late adulthood. Siblings have typically experienced similar environments during childhood, and exhibit negligible population stratification relative to each other. Therefore, the ability to predict differences in disease risk or complex trait values betwe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5f5336c-e217-515e-8a9a-c5eb1e2ef2e6
DOI: 10.1101/2020.03.04.976654

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Within-Family Validation of Polygenic Risk Scores and Complex Trait PredictionDOI 10.1101/2020.03.04.976654Read

Sibling validation of polygenic risk scores and complex trait prediction.Semantic proximity Read

From Genotype to Phenotype: Polygenic Prediction of Complex Human Traits.Semantic proximity Read

Within-sibship GWAS improve estimates of direct genetic effectsSemantic proximity Read

Sibling Similarity Can Reveal Key Insights Into Genetic ArchitectureSemantic proximity Read

Development and validation of polygenic scores for within-family prediction of disease risksSemantic proximity Read

Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives.Semantic proximity Read

Sibling similarity can reveal key insights into genetic architecture.Semantic proximity Read

Polygenic Health Index, General Health, and Pleiotropy: Sibling Analysis and Disease Risk ReductionSemantic proximity Read

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.Semantic proximity Read

Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs.Semantic proximity Read

Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestriesSemantic proximity Read

A simple approach for multiple observations improves power to detect genetic effects and genomic prediction accuracy.Semantic proximity Read