Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimating genetic nurture with summary statistics of multigenerational genome-wide association studies.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2021

Wu Yuchang, Zhong Xiaoyuan, Lin Yunong, Zhao Zijie, Chen Jiawen, Zheng Boyan, Li James J, Fletcher Jason M, Lu Qiongshi

Abstract excerpt

Marginal effect estimates in genome-wide association studies (GWAS) are mixtures of direct and indirect genetic effects. Existing methods to dissect these effects require family-based, individual-level genetic, and phenotypic data with large samples, which is difficult to obtain in practice. Here, we propose a statistical framework to estimate direct and indirect genetic effects using summary statistics from GWAS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder
Share to Birth Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Educational Status

Share to Family Characteristics

Share to Genome-Wide Association Study

Share to Linkage Disequilibrium

Share to Multifactorial Inheritance

Share to Statistics as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 34131076
DOI: 10.1073/pnas.2023184118
PMCID: PMC8237646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimating genetic nurture with summary statistics of multigenerational genome-wide association studies.PMID 34131076Read ↗

Estimating genetic nurture with summary statistics of multi-generational genome-wide association studiesSemantic proximity Read ↗

Within-sibship GWAS improve estimates of direct genetic effectsSemantic proximity Read ↗

Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data.Semantic proximity Read ↗

Separating direct, indirect and parent-of-origin genetic effects in the human populationSemantic proximity Read ↗

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.Semantic proximity Read ↗

Separating direct, indirect, and parent-of-origin genetic effects in the human population.Semantic proximity Read ↗

Estimation of Direct and Indirect Polygenic Effects and Gene-Environment Interactions using Polygenic Scores in Case-Parent Trio StudiesSemantic proximity Read ↗

The National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pairs genome-wide data.Semantic proximity Read ↗

Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestriesSemantic proximity Read ↗

Estimation of direct and indirect polygenic effects and gene-environment interactions using polygenic scores in case-parent trio studies.Semantic proximity Read ↗

Robust genetic nurture effects on education: A systematic review and meta-analysis based on 38,654 families across 8 cohorts.Semantic proximity Read ↗

Decomposing heritability and genetic covariance by direct and indirect effect paths.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.