Article

Separating direct, indirect and parent-of-origin genetic effects in the human population

2025-05-01

Abstract excerpt

Here, we present a novel approach to estimate the degree to which the phenotypic effect of a DNA locus is attributable to four components: alleles in the child (direct genetic effects), alleles in the mother and the father (indirect genetic effects), or is dependent upon the parent from which it is inherited (parent-of-origin, PofO effects). Applying our model, JODIE, to 30,000 child-mother-father trios with phase...

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Literature Corpus work: 38c09294-05f8-5348-98ce-d90c9eeb1cae
DOI: 10.1101/2025.04.28.650988

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