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Article

Mendelian imputation of parental genotypes improves estimates of direct genetic effects.

Nature genetics - 1 Jun 2022

Young Alexander I, Nehzati Seyed Moeen, Benonisdottir Stefania, Okbay Aysu, Jayashankar Hariharan, Lee Chanwook, Cesarini David, Benjamin Daniel J, Turley Patrick, Kong Augustine

Abstract excerpt

Effects estimated by genome-wide association studies (GWASs) include effects of alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for example, effects of alleles in parents on offspring through the environment) and bias from confounding. Within-family genetic variation is random, enabling unbiased estimation of direct genetic effects when parents are genotyped....

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Identifiers

PMID: 35681053
DOI: 10.1038/s41588-022-01085-0
PMCID: PMC9197765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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