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Article

Interpreting population- and family-based genome-wide association studies in the presence of confounding.

PLoS biology - 1 Apr 2024

Veller Carl, Coop Graham M

Abstract excerpt

A central aim of genome-wide association studies (GWASs) is to estimate direct genetic effects: the causal effects on an individual's phenotype of the alleles that they carry. However, estimates of direct effects can be subject to genetic and environmental confounding and can also absorb the "indirect" genetic effects of relatives' genotypes. Recently, an important development in controlling for these confounds...

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PMID: 38603516
DOI: 10.1371/journal.pbio.3002511
PMCID: PMC11008796

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