Article

Engineering the Immune Adaptor Protein STING as a Biologic

2021-02-18

Abstract excerpt

<h4>ABSTRACT</h4> Activation of the stimulator of interferon genes (STING) pathway through cyclic dinucleotides (CDNs) has been explored extensively as potent vaccine adjuvants against infectious diseases as well as to increase tumor immunogenicity towards cancer immunotherapy in solid tumors. Over the last decade, a myriad of synthetic vehicles, including liposomes, polymers, and other nanoparticle platforms, ha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fac1b843-2a25-5109-b842-0ef35e289652
DOI: 10.1101/2021.02.18.431824

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering the Immune Adaptor Protein STING as a BiologicDOI 10.1101/2021.02.18.431824Read

Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer ImmunotherapySemantic proximity Read

cGAS-STING pathway in cancer biotherapySemantic proximity Read

Targeted Delivery of STING agonist via Albumin Nanoreactor Boosts Immunotherapeutic Efficacy against Aggressive CancersSemantic proximity Read

Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapySemantic proximity Read

STING Agonist Combined to a Protein-Based Cancer Vaccine Potentiates Peripheral and Intra-Tumoral T Cell Immunity.Semantic proximity Read

Comparative Molecular, Innate, and Adaptive Impacts of Chemically Diverse STING AgonistsSemantic proximity Read

STING-Activating Polymer-Drug Conjugates for Cancer ImmunotherapySemantic proximity Read

T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapySemantic proximity Read

STING Licensing of Type I Dendritic Cells Potentiates Antitumor ImmunitySemantic proximity Read

STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma modelsSemantic proximity Read

Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner.Semantic proximity Read

STING pathway agonism as a cancer therapeuticSemantic proximity Read