Article

Computational insights into the conformational transition of STING: mechanistic, energetic considerations, and the influence of crucial mutations

2023-05-05

Abstract excerpt

STING (stimulator of interferon genes) is a crucial protein in the innate immune system’s response to viral and bacterial infections. In this study, we investigated the mechanistic and energetic mechanism of the conformational transition process of STING activated by cGAMP binding. We found that the STING connector region undergoes an energetically unfavorable transition during this process, which is compensated b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6eb9a32-3984-5d00-86aa-2a2eccc9bf05
DOI: 10.1101/2023.05.03.539334

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational insights into the conformational transition of STING: mechanistic, energetic considerations, and the influence of crucial mutationsDOI 10.1101/2023.05.03.539334Read

Computational insights into the conformational transition of STING: Mechanistic, energetic considerations, and the influence of crucial mutations.Semantic proximity Read

How fragile we are. Influence of STimulator of INterferon Genes, STING, variants on pathogen recognition and immune response efficiencySemantic proximity Read

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutationSemantic proximity Read

Case Report: Novel SAVI-Causing Variants in STING1 Expand the Clinical Disease Spectrum and Suggest a Refined Model of STING Activation.Semantic proximity Read

The mutational landscape of STING-induced immunity.Semantic proximity Read

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligenceSemantic proximity Read

An Integrative Approach to Dissect the Drug Resistance Mechanism of the H172Y Mutation of SARS-CoV-2 Main ProteaseSemantic proximity Read

STING polymer structure reveals mechanisms for activation, hyperactivation, and inhibitionSemantic proximity Read

Crystal structures of porcine STINGCBD–CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteinsSemantic proximity Read

Distinct oligomeric assemblies of STING induced by non-nucleotide agonistsSemantic proximity Read

A novel approach to study multi-domain motions in JAK1's activation mechanism based on energy landscape.Semantic proximity Read

STING inhibitors target the cyclic dinucleotide binding pocket.Semantic proximity Read