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Article

Computational insights into the conformational transition of STING: Mechanistic, energetic considerations, and the influence of crucial mutations.

Journal of molecular graphics & modelling - 1 Jun 2024

Li Zhenlu, Yue Congran, Xie Shangqiang, Shi Sai, Ye Sheng

Abstract excerpt

STING (stimulator of interferon genes) is a crucial protein in the innate immune system's response to viral and bacterial infections. In this study, we investigated the mechanistic and energetic mechanism of the conformational transition process of STING activated by cGAMP binding. We found that the STING connector region undergoes an energetically unfavorable rotation during this process, which is compensated by...

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PMID: 38581901
DOI: 10.1016/j.jmgm.2024.108764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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