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Distinct oligomeric assemblies of STING induced by non-nucleotide agonists

11 Apr 2025

Abstract excerpt

STING plays essential roles coordinating innate immune responses to processes that range from pathogenic infection to genomic instability. Its adaptor function is activated by cyclic dinucleotide (CDN) secondary messengers originating from self (2'3'-cGAMP) or bacterial sources (3'3'-CDNs). Different classes of CDNs possess distinct binding modes, stabilizing STING's ligand-binding domain (LBD) in either a closed...

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PMID: 40216780
DOI: 10.1038/s41467-025-58641-5

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