Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants.

Genetics - 1 Nov 2015

Hamza Akil, Tammpere Erik, Kofoed Megan, Keong Christelle, Chiang Jennifer, Giaever Guri, Nislow Corey, Hieter Philip

Abstract excerpt

While the pace of discovery of human genetic variants in tumors, patients, and diverse populations has rapidly accelerated, deciphering their functional consequence has become rate-limiting. Using cross-species complementation, model organisms like the budding yeast, Saccharomyces cerevisiae, can be utilized to fill this gap and serve as a platform for testing human genetic variants. To this end, we performed two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Complementary
Share to Feasibility Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Essential

Share to Genes, Fungal

Share to Genetic Complementation Test

Share to Genetics, Medical

Share to Neoplasms

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 26354769
DOI: 10.1534/genetics.115.181099
PMCID: PMC4649650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants.PMID 26354769Read ↗

Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins.Semantic proximity Read ↗

Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae.Semantic proximity Read ↗

Humanized yeast to model human biology, disease and evolution.Semantic proximity Read ↗

Identifying pathogenicity of human variants via paralog-based yeast complementation.Semantic proximity Read ↗

Homo cerevisiae-Leveraging Yeast for Investigating Protein-Protein Interactions and Their Role in Human Disease.Semantic proximity Read ↗

Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast.Semantic proximity Read ↗

Gene essentiality and synthetic lethality in haploid human cells.Semantic proximity Read ↗

Mutant power: using mutant allele collections for yeast functional genomics.Semantic proximity Read ↗

Sentinel Interaction Mapping (SIM) – A generic approach for the functional analysis of human disease gene variants using yeastSemantic proximity Read ↗

Exploring the Molecular Underpinnings of Cancer-Causing Oncohistone Mutants Using Yeast as a ModelSemantic proximity Read ↗

A global genetic interaction map of a human cell reveals conserved principles of genetic networksSemantic proximity Read ↗

Plasmid-chromosome shuffling for non-deletion alleles in yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.