Article

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

2024-05-28

Abstract excerpt

<h4>ABSTRACT</h4> With the recent rise in CRISPR/Cas9-mediated genome-wide synthetic lethality screens, many new synthetic lethal targets have been identified for diseases with underlying genetic causes such as tumours with BRCA1 mutations. Such screens often use full deficiency of a protein to identify novel vulnerabilities. However, patient-derived mutations not only result in loss of the protein but often als...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6db389fe-8341-53c7-be2a-18acdc7b74d9
DOI: 10.1101/2024.05.24.595688

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Finding novel vulnerabilities of hypomorphic BRCA1 allelesDOI 10.1101/2024.05.24.595688Read

BAP1 Missense Mutations in Cancer: Friend or Foe?Semantic proximity Read

CRISPR-enabled genetic screens identify synthetic lethal targets across frequently altered cancer driversSemantic proximity Read

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors.Semantic proximity Read

Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool.Semantic proximity Read

Neomorphic mutations create therapeutic challenges in cancer.Semantic proximity Read

Genome annotation by shotgun inactivation of a native gene in hemizygous cells: application to BRCA2 with implication of hypomorphic variants.Semantic proximity Read

65 YEARS OF THE DOUBLE HELIX: The advancements of gene editing and potential application to hereditary cancer.Semantic proximity Read

Mutation of PACS1: the milder end of the spectrum.Semantic proximity Read

Drugging the Cancers Addicted to DNA RepairSemantic proximity Read

Using Cancer Profiles to Identify Synthetic Lethal Therapeutic Targets and Predictive Biomarkers in Cancer Gene Dependency DataSemantic proximity Read

Mapping the human kinome in response to DNA damageSemantic proximity Read

BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality.Semantic proximity Read