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Article

Synthetic Lethal Interactions of RECQ Helicases.

Trends in cancer - 1 Feb 2021

Datta Arindam, Dhar Srijita, Awate Sanket, Brosh Robert M

Abstract excerpt

DNA helicases have risen to the forefront as genome caretakers. Their prominent roles in chromosomal stability are demonstrated by the linkage of mutations in helicase genes to hereditary disorders with defects in DNA repair, the replication stress response, and/or transcriptional activation. Conversely, accumulating evidence suggests that DNA helicases in cancer cells have a network of pathway interactions such...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33041245
DOI: 10.1016/j.trecan.2020.09.001
PMCID: PMC7855770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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