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Molecular mechanisms of HIV integration and therapeutic intervention

1 Feb 2007

Abstract excerpt

Retroviruses, such as human immunodeficiency virus type 1 (HIV-1), are plus-sense RNA viruses that require reverse transcription and then DNA integration to establish a chromosomal provirus as an obligate replication intermediate. The viral enzyme reverse transcriptase synthesises linear double-stranded cDNA, which is the template for the viral enzyme integrase. Integrase catalyses two separate chemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17320002
DOI: 10.1017/s1462399407000257

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