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Article

Key determinants of target DNA recognition by retroviral intasomes

29 Apr 2015

Abstract excerpt

BACKGROUND: Retroviral integration favors weakly conserved palindrome sequences at the sites of viral DNA joining and generates a short (4-6 bp) duplication of host DNA flanking the provirus. We previously determined two key parameters that underlie the target DNA preference for prototype foamy virus (PFV) and human immunodeficiency virus type 1 (HIV-1) integration: flexible pyrimidine (Y)/purine (R) dinucleotide...

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PMID: 25924943
DOI: 10.1186/s12977-015-0167-3

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