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Article

Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

19 Feb 2009

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19229293
DOI: 10.1038/emboj.2009.41

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Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactorPMID 19229293Read ↗

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Semantic proximity Read ↗

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapySemantic proximity Read ↗

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA IntegrationSemantic proximity Read ↗

Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1ReplicationSemantic proximity Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

Molecular mechanisms of HIV integration and therapeutic interventionSemantic proximity Read ↗

An Essential Role for LEDGF/p75 in HIV IntegrationSemantic proximity Read ↗

Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/Transcriptional Co-activator p75 (LEDGF/p75) That Binds HIV-1 IntegraseSemantic proximity Read ↗

Implication of serine residues 271, 273, and 275 in the human immunodeficiency virus type 1 cofactor activity of lens epithelium-derived growth factor/p75.Semantic proximity Read ↗

Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitnessSemantic proximity Read ↗

The ins and outs of HIV replicationSemantic proximity Read ↗

Factors that mold the nuclear landscape of HIV-1 integrationSemantic proximity Read ↗

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