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HIV-1 gene expression: lessons from provirus and non-integrated DNA

25 Jun 2004

Abstract excerpt

Replication of HIV-1 involves a series of obligatory steps such as reverse transcription of the viral RNA genome into double-stranded DNA, and subsequent integration of the DNA into the human chromatin. Integration is an essential step for HIV-1 replication; yet the natural process of HIV-1 infection generates both integrated and high levels of non-integrated DNA. Although proviral DNA is the template for...

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PMID: 15219234
DOI: 10.1186/1742-4690-1-13

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