Article
RNA structures facilitate recombination-mediated gene swapping in HIV-1.
Journal of virology - 1 Dec 2010
Simon-Loriere Etienne, Martin Darren P, Weeks Kevin M, Negroni Matteo
Abstract excerpt
Many viruses, including retroviruses, undergo frequent recombination, a process which can increase their rate of adaptive evolution. In the case of HIV, recombination has been responsible for the generation of numerous intersubtype recombinant variants with epidemiological importance in the AIDS pandemic. Although it is known that fragments of genetic material do not combine randomly during the generation of...
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