Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Factors that mold the nuclear landscape of HIV-1 integration

27 Nov 2020

Abstract excerpt

The integration of retroviral reverse transcripts into the chromatin of the cells that they infect is required for virus replication. Retroviral integration has far-reaching consequences, from perpetuating deadly human diseases to molding metazoan evolution. The lentivirus human immunodeficiency virus 1 (HIV-1), which is the causative agent of the AIDS pandemic, efficiently infects interphase cells due to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33337475
DOI: 10.1093/nar/gkaa1207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Factors that mold the nuclear landscape of HIV-1 integrationPMID 33337475Read ↗

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA IntegrationSemantic proximity Read ↗

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modificationSemantic proximity Read ↗

Nuclear Import of the Pre-Integration Complex (PIC): The Achilles Heel of HIV ?Semantic proximity Read ↗

Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integrationSemantic proximity Read ↗

HIV-1 Proviral Transcription and Latency in the New EraSemantic proximity Read ↗

HIV-1 capsid and viral DNA integrationSemantic proximity Read ↗

Remodeling of the core leads HIV-1 pre-integration complex in the nucleus of human lymphocytesSemantic proximity Read ↗

HIV-1 uncoats in the nucleus near sites of integrationSemantic proximity Read ↗

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral IntegrationSemantic proximity Read ↗

A model for cofactor use during HIV-1 reverse transcription and nuclear entrySemantic proximity Read ↗

Molecular mechanisms of HIV integration and therapeutic interventionSemantic proximity Read ↗

Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integrationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.