Article

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

2021-07-20

Abstract excerpt

Establishment of the interferon (IFN)-mediated antiviral state provides a crucial initial line of defense against viral infection. Numerous genes that contribute to this antiviral state remain to be identified. Using a loss-of-function strategy, we screened an original library of 1156 siRNAs targeting 386 individual curated human genes in stimulated microglial cells infected with Zika virus (ZIKV), an emerging RNA...

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Literature Corpus work: f337397d-1821-5983-b0c0-7c8c46dc45ae
DOI: 10.1101/2021.07.20.453077

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