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Intrinsic features of Zika Virus non-structural proteins NS2A and NS4A in the regulation of viral replication

6 May 2022

Abstract excerpt

Zika virus (ZIKV) is a mosquito-borne flavivirus and can cause neurodevelopmental disorders in fetus. As a neurotropic virus, ZIKV persistently infects neural tissues during pregnancy but the viral pathogenesis remains largely unknown. ZIKV has a positive-sense and single-stranded RNA genome, which encodes 7 non-structural (NS) proteins, participating in viral replication and dysregulation of host immunity. Like...

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PMID: 35522620
DOI: 10.1371/journal.pntd.0010366

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