Article
Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus
30 Aug 2024
Abstract excerpt
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that can have devastating health consequences. The developmental and neurological effects of a ZIKV infection arise in part from the virus triggering cellular stress pathways and perturbing transcriptional programs. To date, the underlying mechanisms of transcriptional control directing viral restriction and virus-host interaction are understudied....
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