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Zika Virus Proteins NS2A and NS4A Are Major Antagonists that Reduce IFN-�� Promoter Activity Induced by the MDA5/RIG-I Signaling Pathway

28 Oct 2019

Abstract excerpt

Zika virus (ZIKV) is a mosquito-transmitted, emerging Flavivirus that causes Guillain-Barré syndrome and microcephaly in adults and fetuses, respectively. Since ZIKV was first isolated in 1947, severe outbreaks have occurred at various places worldwide, including Yap Island in 2007, French Polynesia in 2013, and Brazil in 2015. Although incidences of ZIKV infection and dissemination have drastically increased,...

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PMID: 31581385
DOI: 10.4014/jmb.1909.09017

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