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Article

Discovery of Genes that Modulate Flavivirus Replication in an Interferon-Dependent Manner

29 Sept 2021

Abstract excerpt

Establishment of the interferon (IFN)-mediated antiviral state provides a crucial initial line of defense against viral infection. Numerous genes that contribute to this antiviral state remain to be identified. Using a loss-of-function strategy, we screened an original library of 1156 siRNAs targeting 386 individual curated human genes in stimulated microglial cells infected with Zika virus (ZIKV), an emerging...

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Identifiers

PMID: 34599939
DOI: 10.1016/j.jmb.2021.167277

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