Article

Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells

2024-01-21

Abstract excerpt

<h4>Summary</h4> Zika virus (ZIKV) is a mosquito-borne flavivirus that caused an epidemic in the Americas in 2016 and is linked to severe neonatal birth defects, including microcephaly and spontaneous abortion. To better understand the host response to ZIKV infection, we adapted the 10x Genomics Chromium single cell RNA sequencing (scRNA-seq) assay to simultaneously capture viral RNA and host mRNA. Using this ass...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 962391fc-c566-572a-83c8-5a5e7338e454
DOI: 10.1101/2024.01.19.576293

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cellsDOI 10.1101/2024.01.19.576293Read

Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cellsSemantic proximity Read

Single-cell transcriptional dynamics of flavivirus infectionSemantic proximity Read

Transcriptional Changes during Naturally Acquired Zika Virus Infection Render Dendritic Cells Highly Conducive to Viral ReplicationSemantic proximity Read

Single-cell RNA sequencing to understand host-virus interactionsSemantic proximity Read

Zika virus infection in a cell culture model reflects the transcriptomic signatures in patientsSemantic proximity Read

Network Medicine Approach to Viral Infections: Unraveling Universal and Virus-Specific Immune PathwaysSemantic proximity Read

Endogenous ZAP is associated with altered Zika virus infection phenotype.Semantic proximity Read

Bioinformatic analysis reveals the expression of unique transcriptomic signatures in Zika virus infected human neural stem cellsSemantic proximity Read

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophagesSemantic proximity Read

West Nile virus-inclusive single-cell RNA sequencing reveals heterogeneity in the type I interferon response within single cellsSemantic proximity Read

Zika infection of neural progenitor cells perturbs transcription in neurodevelopmental pathwaysSemantic proximity Read

Integrated single-cell analysis reveals interferon-driven immune signatures in a DENV1 human infection modelSemantic proximity Read