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Article

Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro

21 Mar 2017

Abstract excerpt

Type I interferon (IFN) serves as the first line of defense against invading pathogens. Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV to evade antiviral responses from host cells. Here we demonstrate that ZIKV nonstructural proteins NS1, NS4B and NS2B3 inhibit the induction of IFN and downstream IFN-stimulated genes through diverse strategies. NS1 and NS4B of...

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PMID: 28373913
DOI: 10.1038/celldisc.2017.6

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