Article

Copy number variant heterogeneity among cancer types reflects inconsistent concordance with diagnostic classifications

2021-03-01

Abstract excerpt

Due to frequent genome instability and accumulation of mutations during the neoplastic process, malignant tumors present with patterns of somatic genome variants on diverse levels of heterogeneity. The delineation of pathophysiological consequences of these patterns remains one of the main challenges in cancer prognosis and treatment. Although continuous efforts aim for better characterization of cancer entities t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f33059bf-be33-50a8-8cab-a8db8da0cacf
DOI: 10.1101/2021.03.01.433348

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Copy number variant heterogeneity among cancer types reflects inconsistent concordance with diagnostic classificationsDOI 10.1101/2021.03.01.433348Read

Copy number variation heterogeneity reveals biological inconsistency in hierarchical cancer classificationsSemantic proximity Read

CNA Explorer and anaLyzer (CNAEL): an interactive web application and standard operating procedure enabling efficient clinical review and reporting of complex NGS-derived tumor copy number profilesSemantic proximity Read

Copy Number Alteration Signatures As Biomarkers in Cancer: A ReviewSemantic proximity Read

The repertoire of copy number alteration signatures in human cancerSemantic proximity Read

The repertoire of copy number alteration signatures in human cancer.Semantic proximity Read

CNApp: quantification of genomic copy number alterations in cancer and integrative analysis to unravel clinical implicationsSemantic proximity Read

Signatures of copy number alterations in human cancer.Semantic proximity Read

Signatures of copy number alterations in human cancerSemantic proximity Read

CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications.Semantic proximity Read

Systematic identification of mutations and copy number alterations associated with cancer patient prognosis.Semantic proximity Read

Candidate targets of copy number deletion events across 17 cancer typesSemantic proximity Read

Cancer classification in the genomic era: five contemporary problemsSemantic proximity Read