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Article

CNApp, a tool for the quantification of copy number alterations and integrative analysis revealing clinical implications.

eLife - 15 Jan 2020

Franch-Expósito Sebastià, Bassaganyas Laia, Vila-Casadesús Maria, Hernández-Illán Eva, Esteban-Fabró Roger, Díaz-Gay Marcos, Lozano Juan José, Castells Antoni, Llovet Josep Maria, Castellví-Bel Sergi, Camps Jordi

Abstract excerpt

Somatic copy number alterations (CNAs) are a hallmark of cancer, but their role in tumorigenesis and clinical relevance remain largely unclear. Here, we developed CNApp, a web-based tool that allows a comprehensive exploration of CNAs by using purity-corrected segmented data from multiple genomic platforms. CNApp generates genome-wide profiles, computes CNA scores for broad, focal and global CNA burdens, and uses...

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Identifiers

PMID: 31939734
DOI: 10.7554/eLife.50267
PMCID: PMC7010409

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