Article

Lineage-aware stochastic modeling reveals gene-expression dynamics in development and disease

2026-06-28

Abstract excerpt

Gene expression changes along cell lineages, but most single-cell RNA-seq analyses treat cells as independent snapshots and ignore their phylogenetic relationships. Here we present LaVOUS, a lineage-aware probabilistic framework for modeling sparse single-cell gene-expression counts on reconstructed lineage trees. LaVOUS couples Brownian motion and Ornstein–Uhlenbeck models of latent transcriptional dynamics with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b5982fd-64c9-57c2-8499-70a322f6db3f
DOI: 10.64898/2026.06.25.734628

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lineage-aware stochastic modeling reveals gene-expression dynamics in development and diseaseDOI 10.64898/2026.06.25.734628Read

Deep Lineage: Single-Cell Lineage Tracing and Fate Inference Using Deep LearningSemantic proximity Read

DyMoTree decodes early cell state transitions and drivers from single-cell transcriptomes using a tree-structured neural networkSemantic proximity Read

Deciphering Cell Fate and Clonal Dynamics via Integrative Single-Cell Lineage ModelingSemantic proximity Read

Learning dynamics by computational integration of single cell genomic and lineage informationSemantic proximity Read

Learning dynamics by computational integration of single cell genomic and lineage informationSemantic proximity Read

Deciphering Cell Fate and Clonal Dynamics via Integrative Single-Cell Lineage ModelingSemantic proximity Read

MiTo: tracing the phenotypic evolution of somatic cell lineages via mitochondrial single-cell multi-omicsSemantic proximity Read

SCOUT: Ornstein–Uhlenbeck modelling of gene expression evolution on single-cell lineage treesSemantic proximity Read

Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specificationSemantic proximity Read

CellRank 2: unified fate mapping in multiview single-cell dataSemantic proximity Read

Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolutionSemantic proximity Read

Unified fate mapping in multiview single-cell dataSemantic proximity Read